If you must run multiple apps, keep in mind the golden rule - Two anti-virus programs is one too many. The latest anti-virus tests from AV-Comparatives show how well most anti-virus apps protect you from all sorts of malware. Most can't even agree on whether it's AntiVirus, Antivirus, or Anti-Virus.
The best bet today is to wrap them all up into one word - malware.
Nowadays, you have viruses, malware, spyware, worms, trojans, rootkits, rogues, adware, PUP's, and that's just off the top of our head.
Not too long ago, it was pretty simple - You had viruses. Of course, most anti-malware apps (Malwarebytes, IObit Malware Fighter) now work as anti-virus protection as well. So the reality is that you don't need an additional anti-malware app because you're already protected if you're running an anti-virus program. Anti-virus suites (AVG, Avast, Avira, BitDefender, McAfee, Norton, Windows Defender) have come a long way and now detect and block most known threats. To answer the question, we need to understand that times have changed. Here's a loaded question that we see a lot - Which anti-malware app is best, and will it play well with my anti-virus?